Long-term hearing outcomes of children with symptomatic congenital CMV treated with valganciclovir
نویسندگان
چکیده
منابع مشابه
996Predictors of Sensorineural Hearing Loss (SNHL) in Infants with Symptomatic Congenital CMV Infection
Background. Congenital CMV (cCMV) is the leading non-genetic cause of sensorineural hearing loss (SNHL) in the U.S. Approximately 40-60% of infants with symptomatic cCMV infection develop long term sequelae such as hearing loss. Currently, there are no identified predictors of hearing loss. The objectiveis to determine clinical predictors of SNHL in infants with symptomatic cCMV infection. Meth...
متن کاملValganciclovir for symptomatic congenital cytomegalovirus disease.
BACKGROUND The treatment of symptomatic congenital cytomegalovirus (CMV) disease with intravenous ganciclovir for 6 weeks has been shown to improve audiologic outcomes at 6 months, but the benefits wane over time. METHODS We conducted a randomized, placebo-controlled trial of valganciclovir therapy in neonates with symptomatic congenital CMV disease, comparing 6 months of therapy with 6 weeks...
متن کاملClinical profile of hearing loss in children with congenital cytomegalovirus (CMV) infection: CMV DNA diagnosis using preserved umbilical cord
CONCLUSIONS Congenital cytomegalovirus (CMV) infection is a major cause of bilateral and unilateral sensorineural hearing loss (SNHL) in children, accounting for 9.0% of SNHL cases. The diagnostic rate using combined genetic deafness test and CMV DNA detection test was determined to be 46.4% in bilateral profound SNHL. OBJECTIVES The present study investigated the prevalence of congenital CMV...
متن کاملCongenital CMV infection; diagnosis in symptomatic infants.
BACKGROUND Samples from babies exhibiting clinical symptoms suggestive of congenital infection are referred regularly to NICD, New Delhi,, from Government Hospitals located in Delhi and a home for abandoned children (Palna), for the diagnosis of etiological agents like toxoplasma, rubella, CMV and herpes. Blood samples of mothers of most of the affected babies are also received. OBJECTIVE Eva...
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BACKGROUND Steroid-resistant nephrotic syndrome (SRNS) is an important cause of chronic kidney disease (CKD) in children that often progresses to end-stage renal disease (ESRD). Calcineurin inhibitors (CNIs) have been shown to be effective in inducing short-term remission in some patients with SRNS. However, there are little data examining their long-term impact on ESRD progression rates. MET...
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ژورنال
عنوان ژورنال: International Journal of Pediatric Otorhinolaryngology
سال: 2019
ISSN: 0165-5876
DOI: 10.1016/j.ijporl.2018.12.027